They try standard treatments first, but when those fail, as they did in Ben and Sam’s cases, they turn to drugs that might not be approved for epilepsy or even for children. Some of these drugs might cause severe side effects, including fits of rage or sedation so extreme that, as one mother described it to me, “the light goes out” in a child’s eyes. For example, last year Denver’s mayor announced that more than 10,000 convictions for low-level marijuana crimes, going back to 2001, would be eligible for expungement. Where Jacobson and Nussenbaum saw their role as helping a cannabis-derived drug get F.D.A. approval, Figi focused on legislation, becoming a kind of CBD ambassador. She testified before State Legislatures and helped draft a 2017 House bill that, if it hadn’t died, would have legalized CBD nationally.
Not all of those compounds are unique to marijuana, of course, and appear in many other species of plants. That’s why marijuana can smell like pine trees or taste like fresh lemons. But of those 400 compounds, more than 60 of them are totally specific to the plant genus Cannabis.
Although CBD does not activate our cannabinoid receptors, it does modify their response to other cannabinoids like THC. Essentially, this means that when used alone, like in the form of an isolate, CBD does not cause euphoria or paranoia, nor should it cause other effects associated with THC. Unlike THC, CBD is non-intoxicating, meaning that it does not produce a “high,” even in large doses. THC also binds to our CB2 receptors, another kind of cannabinoid receptor found throughout our lymphatic systems, reducing inflammation. Whereas THC activates our cannabinoid receptors, CBD has actually been shown to modulate the response of these receptors when THC is present.
One of the most sought-after uses for CBD stems from its anti-inflammatory properties which provide consistent pain management for patients. While many gravitate towards CBD for physical symptoms, there’s growing research to support its effectiveness against mental health conditions as well. New studies show decreases in anxiety levels among those using CBD. This is something most of us can relate to on some level; as there’s a constant stream of stressful situations waiting to be thrown at us daily.
“If you’re taking Prozac or some other medication, you really need to think carefully about what you’re doing, because it can harm you, and you should talk to your doctor about it,” says Blessing. Blessing does note CBD hemp oil for sale that while the drug interactions are potentially very serious, the doses in consumer CBD products are so low that the risk is likely minimal. Regardless, the fact that CBD has drug interactions should indicate that it is, at least sometimes, in some doses, actually doing something.
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Research has shown CBD to be safe in the short-term when ingested or applied to skin, Alan said, although she cautioned against the possible risks of inhaling CBD oil through a vape pen. The strongest CBD research involves using the substance control epileptic seizures, Alan said.
Others at the high-quality end of the market areApothemandProvacan, both selling hemp-derived, lab-tested products. Provacan recently commissioned a study of 2,000 adults into attitudes towards CBD. It found that most people still think it is illegal, and banned in professional sports.
To understand how CBD works in the body, first we have to get a basic understanding of the endocannabinoid system. This is a system of neurotransmitters and receptors that is found throughout the body. Its receptors appear in the brain, organs, skin, immune cells, and more. All of this shows a major shift in the way mainstream medical professionals—and consumers—have thought about cannabis and CBD. In humans, Cooper emphasized that oft-cited studies regarding CBD’s pain-relieving properties looked at it in combination with THC.